What Is NAD+ and Why Does It Decline?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell of the body, essential for energy production, DNA repair, and cellular communication. By the time we reach 50, NAD+ levels have dropped by approximately 50% from our peak — a decline directly linked to the hallmarks of ageing.
The Science Behind NAD+ Supplementation
Research published in leading journals including Cell Metabolism and Nature has demonstrated that restoring NAD+ levels can improve mitochondrial function, activate sirtuins (longevity proteins), and improve cellular repair mechanisms. Both IV NAD+ infusions and oral precursors (NMN, NR) have shown promising results in clinical studies.
IV NAD+ vs Oral Precursors
IV NAD+ Infusions
Direct intravenous NAD+ delivers the highest bioavailability. Clinical protocols typically involve 250–500mg infusions over 2–4 hours, repeated weekly or monthly for maintenance. Reported benefits include improved cognitive clarity, physical energy, and mood stabilisation.
NMN and NR Oral Supplementation
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are precursors converted to NAD+ in the body. Oral supplementation is more convenient but delivers lower bioavailability than IV protocols.
Who Should Consider NAD+ Therapy?
High-performing executives, athletes, and health-conscious individuals over 35 are the primary candidates for NAD+ optimisation. Those experiencing cognitive fatigue, reduced physical recovery, or early metabolic decline may benefit most significantly.
FAQ
Is NAD+ therapy safe?
IV NAD+ has a strong safety profile when administered by qualified medical professionals. Side effects during infusion (flushing, nausea) are manageable with proper protocol.
How quickly do you feel the effects of NAD+ therapy?
Many patients report improved energy and mental clarity within 24–48 hours of their first IV session. Sustained benefits develop over 4–6 weeks of a structured protocol.