Vagus nerve stimulation has solid clinical evidence in epilepsy and treatment-resistant depression, and the inflammatory reflex mechanism is genuinely compelling — but consumer tVNS devices for wellness have thin supporting evidence and modest effect sizes.
CRISPR-Cas9 is one of the most powerful biological tools ever developed — but self-experimentation carries off-target mutation risks, unresolved delivery challenges, and legal consequences that make it categorically different from other biohacking.
GLP-1 receptor agonists like semaglutide have compelling cardiovascular and metabolic data, but their use in metabolically healthy people for longevity benefits is still unproven — and the muscle loss risk is a real concern that’s often underplayed.
GLP-1s for Metabolic Reset: Should Healthy People Take Ozempic for Longevity? Read More »
GrimAge and DunedinPACE are the most predictive biological age tools ever developed — but using them as personal intervention scorecards runs ahead of the science, and the anxiety they generate can itself accelerate aging.
Epigenetic Clocks: How GrimAge and DunedinPACE Measure Biological Age — and Their Limits Read More »
Young blood transfusions captured Silicon Valley’s imagination after compelling mouse parabiosis studies — but the FDA has warned against commercial plasma clinics, the search for specific active factors has proven elusive, and ethical concerns remain unresolved.
Methylene blue has a century of medical history, a legitimate mitochondrial mechanism, and real drug interaction risks that the biohacking community often downplays — here’s a balanced look at what the science actually supports.
Methylene Blue as a Mitochondrial Enhancer: Biohacking’s Favorite Industrial Dye Read More »
Exosomes are real cellular communicators with genuine therapeutic potential — but commercial longevity clinics are selling uncharacterized, unregulated products that the FDA says shouldn’t be used in humans. Here’s what the evidence actually supports.
Exosome Therapy for Longevity: Promise, Hype, and the Regulatory Wild West Read More »
Senescent ‘zombie cells’ accumulate with age and drive chronic inflammation — senolytics like fisetin, quercetin, and dasatinib are designed to clear them, with early human trial results showing real promise but significant gaps remaining.
Senolytics and Zombie Cell Clearance: Can Fisetin and Quercetin Slow Aging? Read More »
Rapamycin has extended lifespan in every major animal study that tested it, and longevity physicians are increasingly prescribing it off-label — but the human evidence is still incomplete and the immunosuppression risks are real.
BPC-157 and TB-500 are the most-discussed peptides in biohacking recovery circles — but with zero human clinical trials and a gray-market supply chain, the science is far behind the hype. Here’s what the evidence actually shows.
