Zone 2 training is low-intensity aerobic exercise — the conversational pace where you can still talk in full sentences — held long enough to remodel your mitochondria and, over time, lift your VO2 max. That matters for lifespan because VO2 max is one of the single strongest predictors of all-cause mortality we have, rivalling or […]
Zone 2 Training & VO2 Max for Longevity: The Science Read More »
Time-restricted eating — confining all your food to a set daily window, commonly eight to ten hours — reliably improves several metabolic markers and is an easy way to eat fewer calories without counting them. Its popular rationale is autophagy, the cell’s recycling system, but the honest position is that autophagy activation by fasting is
Time-Restricted Eating & Longevity: Autophagy and the Evidence Read More »
Taurine briefly became the longevity world’s favourite molecule after a major 2023 study suggested that its decline might help drive ageing — and that supplementing it extended lifespan in mice. It’s a genuinely interesting finding. But the human case for taurine and longevity is far weaker than headlines implied, and a wave of 2025 research
Taurine and Longevity: What the Science Really Says Read More »
Spermidine is a naturally occurring polyamine that switches on autophagy — the cell’s recycling and self-cleaning programme — which is one of the most consistently life-extending mechanisms in laboratory biology. The strongest human data so far are observational: people who eat more spermidine-rich food tend to live longer and have less cardiovascular disease. The intervention
Spermidine Longevity: Autophagy, Evidence & Dosing Read More »
Omega-3 fatty acids are one of the few nutritional interventions with randomised-trial evidence for slowing biological ageing as measured by epigenetic clocks. In the 2025 DO-HEALTH analysis, daily omega-3 slowed several markers of ageing modestly, and in combination with vitamin D and strength training the effect was larger still. The case for omega-3 and longevity
Fisetin is a plant flavonoid — found most abundantly in strawberries — that has drawn serious scientific interest as a natural senolytic: a compound that selectively clears worn-out “senescent” cells linked to ageing. The animal data are genuinely promising, including lifespan extension in old mice. But the human evidence is still early, the doses used
Fisetin: The Natural Senolytic, Explained by Science Read More »
Creatine is best known as a gym supplement, but its most interesting longevity role has little to do with lifting heavier. It helps preserve muscle and strength as you age — the single biggest modifiable predictor of independence in later life — and a growing body of trial evidence suggests it also supports brain energy
Creatine Longevity: Muscle, Brain & Dosing Guide Read More »
Of the trio of temperature-based “longevity” habits — cold plunges, sauna and contrast therapy — the sauna has by far the strongest evidence, anchored by a large Finnish cohort linking frequent use to lower cardiovascular and all-cause mortality. Cold plunges have real but narrower proof, mostly for mood, alertness and muscle-soreness recovery, while the fat-loss
Cold Plunge, Sauna & Longevity: What the Science Says Read More »
The honest answer to “what are the best longevity supplements in 2026?” is that a handful have solid human evidence, several are promising but unproven, and most of the hyped names are still running on mouse data and marketing. Below we rank nine of the most talked-about options by strength of human evidence — not
Best Longevity Supplements 2026 (Ranked by Evidence) Read More »
What Is NAD+ and Why Does It Decline? Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell of the body, essential for energy production, DNA repair, and cellular communication. By the time we reach 50, NAD+ levels have dropped by approximately 50% from our peak — a decline directly linked to the hallmarks
NAD+ Therapy in 2026: What the Latest Science Says About Cellular Rejuvenation Read More »
