Metformin and rapamycin are the two repurposed prescription drugs most often floated as longevity tools, and they are frequently lumped together. They shouldn’t be. They act on overlapping but distinct pathways, the strength of evidence behind them is very different, and they carry very different risk profiles. If you’re weighing metformin vs rapamycin, the single […]
Metformin vs Rapamycin for Longevity: Head-to-Head Read More »
Metformin is a cheap, generic type 2 diabetes drug that has become one of the most talked-about candidates for slowing human ageing. The theory is biologically plausible and the animal data are intriguing, but the honest summary is this: no trial has yet shown that metformin extends lifespan or healthspan in people who don’t have
Metformin for Longevity & the TAME Trial: The Evidence Read More »
Longevity for women is not simply longevity for men scaled down. Women live longer on average but spend more years in poor health, and the menopause transition is a pivotal window where several aging markers accelerate at once — bone, muscle, cardiovascular and metabolic health all shift as oestrogen falls. The evidence-based priorities are concrete:
Longevity for Women: Menopause, HRT & Healthspan Read More »
Klotho is a protein named after the Greek Fate who spun the thread of life — and the name fits. Mice bred to lack it age prematurely; mice engineered to make more of it live longer. In humans, a common genetic variant that raises klotho levels is linked to sharper cognition and better ageing, and
Klotho Protein and Longevity: The Science Explained Read More »
Fisetin is a plant flavonoid — found most abundantly in strawberries — that has drawn serious scientific interest as a natural senolytic: a compound that selectively clears worn-out “senescent” cells linked to ageing. The animal data are genuinely promising, including lifespan extension in old mice. But the human evidence is still early, the doses used
Fisetin: The Natural Senolytic, Explained by Science Read More »
Creatine is best known as a gym supplement, but its most interesting longevity role has little to do with lifting heavier. It helps preserve muscle and strength as you age — the single biggest modifiable predictor of independence in later life — and a growing body of trial evidence suggests it also supports brain energy
Creatine Longevity: Muscle, Brain & Dosing Guide Read More »
Coenzyme Q10 is one of the few longevity-adjacent supplements with a genuinely positive randomised trial behind it: in people with chronic heart failure, CoQ10 cut mortality and major cardiac events roughly in half. That is a real, specific result — but it was in a sick population, not healthy people chasing extra decades. For most
CoQ10 Longevity: Heart Health, Ubiquinol & Dosing Read More »
Continuous blood monitoring and wearables promise a real-time view of your physiology, and for longevity-minded professionals that is genuinely useful — within limits. Continuous glucose monitors, heart-rate and HRV trackers, sleep sensors and emerging at-home biomarker tools can surface patterns you would otherwise miss. But the gap between what these devices measure accurately and what
Continuous Blood Monitoring for Longevity: Hype vs Use Read More »
Of the trio of temperature-based “longevity” habits — cold plunges, sauna and contrast therapy — the sauna has by far the strongest evidence, anchored by a large Finnish cohort linking frequent use to lower cardiovascular and all-cause mortality. Cold plunges have real but narrower proof, mostly for mood, alertness and muscle-soreness recovery, while the fat-loss
Cold Plunge, Sauna & Longevity: What the Science Says Read More »
The honest answer to “what are the best longevity supplements in 2026?” is that a handful have solid human evidence, several are promising but unproven, and most of the hyped names are still running on mouse data and marketing. Below we rank nine of the most talked-about options by strength of human evidence — not
Best Longevity Supplements 2026 (Ranked by Evidence) Read More »
