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How Tiny Vesicles May One Day Heal the Aging Heart: The Promise of Extracellular Vesicle Therapy

As longevity science continues to explore new frontiers in regenerative medicine, one area that is capturing increasing attention is cardiac health — and the possibility of actually repairing damage rather than merely managing symptoms. In this realm, a new class of therapeutic agents has emerged that may eventually revolutionize how we approach heart disease: extracellular […]

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The Quiet Power of Urolithin A: Healing Inflammation, Cell by Cell

As we grow older, it’s not just the mirror that reflects change—our bodies undergo silent but powerful transformations at the cellular level. One of the most insidious of these changes is chronic inflammation driven by aging cells, a process known as inflammaging. But what if a molecule produced by our gut could help quiet this

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Ginkgolide B: A Natural Compound Extending Healthspan and Lifespan in Female Mice — What It Means for Human Longevity

As modern longevity science continues to evolve, researchers are exploring not only sophisticated gene editing technologies and cutting-edge pharmaceuticals, but also the remarkable untapped potential of naturally occurring compounds. Among these, ginkgolide B—a bioactive compound found in the ancient Ginkgo biloba tree—is attracting new attention for its ability to extend both healthspan and lifespan, at

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The TFEB Paradox: How a Longevity-Linked Protein May Contribute to Cellular Senescence

Exploring the dual nature of TFEB in promoting cell survival — and potentially aging In the quest to understand aging, researchers often discover molecules that appear to hold remarkable promise for extending healthspan and cellular vitality. Among these, TFEB (Transcription Factor EB) has attracted significant interest for its role in regulating autophagy — the body’s

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Ending Atherosclerosis: How Cyclarity and Dr. Matthew O’Connor Are Targeting Aging’s Most Dangerous Disease

Aging is a complex journey, but among its many threats, one remains a leading global killer: atherosclerosis. This gradual buildup of plaque in the arteries underlies most heart attacks and strokes — diseases that claim millions of lives every year. Despite decades of medical progress, atherosclerosis remains largely managed, not reversed. But what if we

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Breaking the Limits of Aging: How a Dual Drug Strategy Boosted Lifespan in Mice by Over 30%

What if the secret to a longer, healthier life wasn’t one miracle drug—but two working in concert? A groundbreaking study published in Nature Aging may be reshaping how we think about longevity. Researchers found that a powerful combination of two pharmaceutical agents—rapamycin and trametinib—could extend the lifespan of mice by more than 30%. And beyond

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How a Natural Molecule from Your Gut Could Help You Age Better: The Promise of Urolithin A

Reframing Aging: From Inevitable Decline to Manageable Biology Aging often feels like a slow surrender—one we can’t see or feel in the moment, but that over time shapes our energy, our resilience, and our health. Yet a growing body of research tells a different story. Aging isn’t simply a matter of passing years. It’s a

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