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Spermidine: The Molecule That May Help Protect Cognitive Function Across Species

How this natural compound is showing promise for brain health and longevity in flies, mice, and humans For anyone invested in the science of healthy aging, cognitive resilience sits at the very heart of the conversation. Preserving memory, focus, and mental clarity as we age isn’t simply about adding more years to life — it’s […]

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How Processed Is Your Food? A New Database Offers Honest Answers

And why understanding food processing may be more important to your longevity than calories or carbs In today’s age of health-conscious eating, we’ve come to scrutinize labels for fat, carbs, sugar, and sodium. But there’s one factor that may matter even more—and is often invisible at first glance: how processed a food really is. A

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From Gut to Grace: How Urolithin A Could Help Rewrite the Story of Aging and Inflammation

Rethinking Aging from the Inside Out Aging is no longer seen as an uncontrollable march toward decline. It’s increasingly understood as a dynamic biological process, shaped by how well our cells manage stress, repair damage, and adapt to change. At the core of this process lies inflammation—specifically, a quiet but chronic type that builds up

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The OSKM Breakthrough: Reprogramming Cells for Youth and Longevity

How four powerful genes may one day allow us to reset aging from within—without starting over Imagine being able to press a biological “reset” button—one that rejuvenates old cells, repairs damage, and restores youthful function without erasing identity. While it sounds like science fiction, this vision is rapidly approaching reality through a remarkable scientific tool

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Powerhouse Under Siege: How Mitochondrial Damage May Drive Type 2 Diabetes

Rethinking Metabolism, Aging, and Energy from the Cellular Core When we think of type 2 diabetes, the first culprits that come to mind are often sugar, insulin, or perhaps lifestyle choices like diet and exercise. But scientists are increasingly turning their attention inward—deep into the cell—to uncover a less obvious but fundamental player: the mitochondria.

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Rejuvenation Roundup: May 2025

From advanced gene silencing to lab-grown tissues and more accurate biomarkers, this month in longevity science brought precision and possibility together As spring unfolded in the Northern Hemisphere, the field of longevity research blossomed with a wave of scientific breakthroughs that emphasized a compelling trend: we’re moving from abstract theory to targeted, actionable precision in

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The Small but Mighty Molecule Offering New Hope in Atherosclerosis

How cutting-edge research is unlocking the potential of a novel molecule to target the root causes of cardiovascular aging Few health threats cast a shadow as wide as atherosclerosis. This silent, progressive hardening and narrowing of the arteries remains one of the world’s leading causes of death, responsible for heart attacks, strokes, and vascular dementia.

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Urolithin A: A Natural Gut Metabolite Quietly Transforming the Science of Aging

Rethinking Aging from the Inside Out Aging has long been thought of as a linear journey—time passes, and the body gradually declines. But recent discoveries in molecular biology and microbiome science are showing that aging is far more dynamic and modifiable than we ever imagined. At the heart of this transformation is a small, gut-derived

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Cellular Senescence and the Future of Aging: A Conversation with Marco Quarta

In the quest to extend human healthspan, one concept has emerged as both a culprit and a potential therapeutic target: cellular senescence. These are cells that, although still alive, have stopped dividing and begun secreting inflammatory and tissue-degrading signals. Scientists have come to see them not just as bystanders in aging—but as active drivers of

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Have We Reached the Limits of Human Lifespan? Rethinking Life Expectancy in the Longevity Era

For centuries, life expectancy has risen almost like clockwork. Advances in sanitation, antibiotics, vaccines, nutrition, and modern medicine have driven remarkable increases in how long humans live. In the early 20th century, global average life expectancy hovered around 30 to 40 years. Today, many high-income countries have averages nearing 80 and beyond. But in recent

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