Cell & Gene Research

The Role of Senescent Macrophages in Aging: A New Frontier in Longevity Science

How targeting these specialized immune cells may offer novel ways to slow aging and extend healthspan In the intricate and rapidly evolving world of aging research, cellular senescence has emerged as one of the most intriguing — and most complex — hallmarks of aging. The idea that our own cells may gradually turn into dysfunctional […]

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Fighting Alzheimer’s from Within: How Supporting Neurons’ Protein Recycling May Help Combat Neurodegeneration

Alzheimer’s disease continues to be one of the most formidable challenges in modern medicine—a progressive condition that robs millions of their memory, cognition, and independence. While decades of research have shed light on its complex pathology, effective treatments remain elusive. However, a promising frontier in Alzheimer’s research is emerging: rather than focusing solely on clearing

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Cracking the Code of Back Pain: A New Target in the Battle Against Spinal Disc Degeneration

How a surprising cellular pathway could reshape the future of spinal health and offer new hope for aging bodies Back pain is a condition so common that many of us accept it as an inevitable part of aging—something to be managed, endured, or medicated, but rarely cured. And at the heart of most chronic back

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Heat Exposure and Epigenetic Aging: How Rising Temperatures May Influence Our Biological Clock

As the science of aging grows more sophisticated, researchers are increasingly focusing on the concept of biological age — a measurement of how old our cells, tissues, and organs truly are, regardless of the number printed on our birth certificate. At the heart of this biological age lies a remarkable new tool: the epigenetic clock,

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Turning Back Time at the Cellular Level: A Conversation with Vittorio Sebastiano of Turn Bio

How partial reprogramming may become one of the most powerful tools in the quest for healthspan extension What if we could rewind the biological clock—not in a metaphoric sense, but in a real, molecular way? What if the cells in your body, worn down by decades of wear, could regain their youthful vigor without losing

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The OSKM Breakthrough: Reprogramming Cells for Youth and Longevity

How four powerful genes may one day allow us to reset aging from within—without starting over Imagine being able to press a biological “reset” button—one that rejuvenates old cells, repairs damage, and restores youthful function without erasing identity. While it sounds like science fiction, this vision is rapidly approaching reality through a remarkable scientific tool

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Powerhouse Under Siege: How Mitochondrial Damage May Drive Type 2 Diabetes

Rethinking Metabolism, Aging, and Energy from the Cellular Core When we think of type 2 diabetes, the first culprits that come to mind are often sugar, insulin, or perhaps lifestyle choices like diet and exercise. But scientists are increasingly turning their attention inward—deep into the cell—to uncover a less obvious but fundamental player: the mitochondria.

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Cellular Senescence and the Future of Aging: A Conversation with Marco Quarta

In the quest to extend human healthspan, one concept has emerged as both a culprit and a potential therapeutic target: cellular senescence. These are cells that, although still alive, have stopped dividing and begun secreting inflammatory and tissue-degrading signals. Scientists have come to see them not just as bystanders in aging—but as active drivers of

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Tiny Technology, Big Hope: How Nanostructures Could Help Stop Alzheimer’s at Its Source

A new frontier in brain health is forming—one that targets the root cause of neurodegeneration with astonishing precision Alzheimer’s disease has long been one of medicine’s most formidable puzzles. Despite decades of research, millions of people around the world still face a future clouded by memory loss, confusion, and progressive cognitive decline. While many treatments

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Turning Back the Clock on Cellular Senescence: A New Discovery Offers Hope for Healthier Aging

How a promising molecular target could help manage “zombie cells” and extend healthspan In the world of longevity science, few concepts have captivated researchers and wellness enthusiasts quite like cellular senescence. Often described as the “zombie cell” phenomenon, senescence refers to cells that have stopped dividing but refuse to die. Instead, they linger in the

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