Drug Development

Urolithin A: The Gut-Derived Molecule Quietly Rewriting How We Age

The New Science of Aging Gracefully For decades, aging was seen as an irreversible march—marked by the gradual decline of organs, energy, and resilience. But recent scientific breakthroughs are turning that narrative on its head. Researchers now view aging not just as a function of time, but of cellular behavior—how well our cells maintain energy, […]

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Rebooting Cellular Health: How Junevity Is Redefining Aging With RNA-Based Reset Therapy

In the dynamic world of longevity science, the frontier is constantly shifting. From senolytics that target aging cells to gene-editing technologies that rewire biology itself, the mission is bold: extend human healthspan, not just lifespan. Now, a new biotech startup named Junevity is emerging with a distinctive strategy—resetting aged cells at the molecular level using

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Fisetin and Vascular Health: How a Natural Compound May Help Prevent Blood Vessel Calcification

As modern science continues to explore the intricate web of aging, one area has drawn increasing attention for its central role in chronic disease and longevity: vascular calcification. The hardening of blood vessels through calcium buildup is a silent but powerful contributor to heart disease, stroke, cognitive decline, and premature aging. While many pharmaceutical approaches

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Inside Bryan Johnson’s Blueprint: A Dinner Conversation on Aging, Ethics, and the Edge of Human Potential

It’s not every day you get invited to dine with a man on a mission to escape death. But that’s precisely what journalist Arkadi Mazin did when he stepped into the world of Bryan Johnson—a tech entrepreneur turned self-experimenting longevity pioneer. At the center of it all? A quiet dinner table, surrounded by biohackers, scientists,

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A Gut-Derived Ally: How Urolithin A May Help Rejuvenate Aging Cells and Calm Inflammation

As we journey through life, our bodies undergo constant transformation. Some of these changes are visible—wrinkles, gray hairs, slower recovery from exertion. Others, more subtle, unfold deep within our cells. One such hidden transformation is a growing wave of low-level, chronic inflammation that quietly contributes to aging and disease. Scientists call it “inflammaging.” But what

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Alpha-Ketoglutarate: The Cellular Ally with Lifespan-Extending Potential

Aging, at its core, is a biological story told through thousands of tiny molecular changes—many of which unfold long before we see a wrinkle or feel a twinge. But what if we could listen in on that story, interpret its signals, and gently nudge it in a healthier direction? One molecule gaining attention for its

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Urolithin A: The Gut-Derived Molecule Quietly Transforming How We Age

In the search for longevity, we often look outward—to new drugs, advanced therapies, or cutting-edge technologies. But what if one of the most promising solutions for healthy aging is something your body can make all on its own? Meet Urolithin A, a molecule born in the gut, crafted by your microbiome from the polyphenols found

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Urolithin A: How a Gut-Derived Molecule May Help Defuse Aging at the Cellular Level

In the expanding field of longevity science, one thing is increasingly clear: aging is not just about time. It’s a biological process—one that is deeply tied to how our cells communicate, repair, and respond to stress. Among the many culprits of age-related decline, chronic low-grade inflammation, or inflammaging, has become a central focus. At the

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Ginkgolide B: A Natural Compound Extending Healthspan and Lifespan in Female Mice — What It Means for Human Longevity

As modern longevity science continues to evolve, researchers are exploring not only sophisticated gene editing technologies and cutting-edge pharmaceuticals, but also the remarkable untapped potential of naturally occurring compounds. Among these, ginkgolide B—a bioactive compound found in the ancient Ginkgo biloba tree—is attracting new attention for its ability to extend both healthspan and lifespan, at

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Ending Atherosclerosis: How Cyclarity and Dr. Matthew O’Connor Are Targeting Aging’s Most Dangerous Disease

Aging is a complex journey, but among its many threats, one remains a leading global killer: atherosclerosis. This gradual buildup of plaque in the arteries underlies most heart attacks and strokes — diseases that claim millions of lives every year. Despite decades of medical progress, atherosclerosis remains largely managed, not reversed. But what if we

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